Addison’s Disease in Dogs

Addison’s Disease in Dogs: Symptoms, Diagnosis, and Treatment

Discover essential information about Addison's Disease in dogs, including signs to watch for, how it's diagnosed, and treatment options to manage this condition effectively. Learn how to support your pet's health and well-being.

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The information provided in this article is intended for general informational purposes only and does not constitute professional veterinary advice. Always consult your veterinarian before administering any medication to your pet. The content was created by AI and should not be used as a substitute for professional veterinary consultation and diagnosis. The Munch Zone and the author assume no responsibility for the use or misuse of this information.

Addison’s Disease, also known as hypoadrenocorticism, is a condition that affects dogs, stemming from an insufficient production of adrenal hormones by the adrenal glands. Located near the kidneys, these glands are essential for regulating various bodily functions, including metabolism and the stress response. While Addison’s Disease can be daunting for pet owners to navigate, understanding its symptoms, causes, diagnosis, and treatment can empower you to provide the best care for your furry friend.

Understanding Addison’s Disease in Dogs

Addison’s Disease occurs when the adrenal glands fail to produce enough corticosteroid hormones, which are crucial for managing stress, metabolism, and electrolyte balance. This deficiency can lead to a range of symptoms and may affect dogs of any breed or age, although it’s more commonly observed in young to middle-aged female dogs.

Symptoms of Addison’s Disease in Dogs8

The signs of Addison’s Disease in dogs can be subtle and may mimic other health conditions, making it challenging to diagnose. Symptoms can vary widely but often include:

  • Lethargy and fatigue
  • Muscle weakness
  • Decreased appetite
  • Vomiting and diarrhea
  • Increased thirst and urination
  • Weight loss
  • Hypoglycemia (low blood sugar)
  • Dehydration
  • Collapse or shock in severe cases

These symptoms can fluctuate in intensity and may appear more pronounced during times of stress, such as boarding, surgery, or illness.

Causes of Addison’s Disease

The primary cause of Addison’s Disease in dogs is an autoimmune response that damages the adrenal glands, leading to decreased hormone production. Other causes can include:

Autoimmune Destruction

The most common cause of Addison’s Disease in dogs is an autoimmune response where the dog’s immune system mistakenly attacks the adrenal cortex. This autoimmune reaction leads to the destruction of adrenal tissue, impairing the glands’ ability to produce essential hormones. The exact trigger for this autoimmune response remains largely unknown, but it is believed to involve a combination of genetic predisposition and environmental factors.

Genetic Predisposition

Research suggests a genetic component to Addison’s Disease, with certain breeds showing a higher incidence of the condition. Breeds such as Standard Poodles, West Highland White Terriers, Portuguese Water Dogs, and Great Danes are at a higher risk. This genetic link suggests that inherited factors play a significant role in the disease’s development, although the specific genes involved have yet to be fully identified.

Adrenal Gland Injury or Trauma

Physical damage to the adrenal glands, whether through trauma, surgery, or infection, can impair their ability to produce hormones. Although less common, such injuries can lead to Addison’s Disease if both adrenal glands are affected. The delicate nature of these glands means that any significant injury can disrupt their normal function.


Adrenal tumors or metastatic cancer affecting the adrenal glands can lead to Addison’s Disease by physically damaging the glandular tissue or disrupting hormone production pathways. While primary adrenal tumors are relatively rare, their impact on hormone production can be profound, leading to the onset of Addison’s symptoms.

Iatrogenic Addison’s Disease

Iatrogenic Addison’s Disease occurs as a result of the sudden withdrawal of corticosteroid medications, which are often prescribed for various inflammatory or autoimmune conditions. These synthetic hormones can cause the adrenal glands to reduce or halt natural hormone production due to the external supply. If the medication is abruptly discontinued without proper tapering, the adrenal glands may not resume normal hormone production quickly enough, leading to Addison’s Disease.

Infectious Diseases

Certain infectious agents, such as fungi, bacteria, and viruses, can directly affect the adrenal glands, leading to Addison’s Disease. These infections can cause inflammation and destruction of the adrenal tissues, impairing hormone production. While relatively rare, these cases highlight the importance of addressing systemic infections promptly to prevent complications like Addison’s Disease.

Environmental and Drug-Induced Factors

Exposure to certain toxins or the use of specific drugs can potentially damage the adrenal glands. While direct links between specific environmental toxins and Addison’s Disease in dogs are not well-established, it’s understood that overall health and exposure to harmful substances can impact adrenal function.

Diagnosing Addison’s Disease

Diagnosing Addison’s Disease involves a thorough veterinary examination, including a review of the dog’s medical history and symptoms. Key diagnostic tests include:

  • Blood tests: To check for electrolyte imbalances, particularly high potassium and low sodium levels, which are indicative of Addison’s Disease.
  • ACTH stimulation test: The most definitive test for diagnosing Addison’s Disease, it measures the adrenal glands’ response to the adrenocorticotropic hormone (ACTH).

Treatment Options

Treatment for Addison’s Disease in dogs focuses on replacing the missing adrenal hormones, primarily through hormone replacement therapy. The main treatments include:

  • Glucocorticoids: To replace cortisol, helping to manage stress and inflammation.
  • Mineralocorticoids: To regulate electrolyte and water balance, either through injections or oral medications.

In addition to hormone replacement, managing stress and avoiding stressful situations are crucial for dogs with Addison’s Disease. Regular monitoring and adjustments to medication may be necessary to ensure optimal health.

Addison’s Disease in Dogs

Living with Addison’s Disease

With proper treatment and care, dogs with Addison’s Disease can lead happy, active lives. Key considerations for managing this condition include:

  • Regular veterinary visits: To monitor the condition and adjust treatment as needed.
  • Diet and nutrition: Providing a balanced diet to support overall health and wellness.
  • Stress management: Reducing stress through routine, gentle exercise, and avoiding stressful situations.


Addison’s Disease in dogs is a serious condition that requires careful management, but with the right approach, it doesn’t have to be a life sentence. Understanding the symptoms, getting a timely diagnosis, and following a comprehensive treatment plan can help your dog lead a full and happy life. If you suspect your dog may have Addison’s Disease, consult your veterinarian as soon as possible to discuss the best course of action.

By educating yourself and staying proactive about your dog’s health, you can navigate the challenges of Addison’s Disease together, ensuring your pet remains a beloved and vibrant member of your family for years to come.

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